منابع مشابه
FOXP3+ Treg Cells and Gender Bias in Autoimmune Diseases
CD4(+)CD25(+) regulatory T (Treg) cells play a pivotal role in the maintenance of immune homeostasis, where the X-linked master transcription factor forkhead box P3 (FOXP3) determines Treg cell development and function. Genetic deficiency of foxp3 induces dysfunction of Treg cells and immuno-dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome in humans. Functionally deficient ...
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BACKGROUND/AIMS Regulatory T cells (Treg) are critical regulators of asthma. Crocetin is isolated from Chinese herb saffron and is a natural carotenoid dicarboxylic acid with anti-inflammatory potential. However, the effects of Crocetin on asthma as well as the underlying mechanisms have not been studied. METHODS We used Crocetin to treat mice with established ovalbumin (OVA)-induced asthma. ...
متن کاملB cells and humoral immunity in atherosclerosis.
Insights into the important contribution of inflammation and immune functions in the development and progression of atherosclerosis have greatly improved our understanding of this disease. Although the role of T cells has been extensively studied for decades, only recently has the role of B cells gained more attention. Recent studies have identified differential effects of different B-cell subs...
متن کاملCCR8+FOXp3+ Treg cells as master drivers of immune regulation.
The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3, CD39, IL-10, and granzyme B, resulting in enhanced suppressive activity of these cells. Of the four h...
متن کاملTreg: tolerance vs immunity
Regulatory T cells (Treg) are requisite for the prevention of autoimmunity, transplant rejection, and tolerance to therapeutic protein delivery. Dendritic cells (DCs) are crucial for FoxP3+ Treg homeostasis, and their expansion can increase Treg numbers. By contrast, Treg are a hindrance to anti-cancer therapy as they suppress immune responses to tumors. Interestingly, some of the same drugs an...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2013
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/dxt060